Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study
Identifieur interne : 005425 ( Main/Exploration ); précédent : 005424; suivant : 005426Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study
Auteurs : Rehana L. Ahmed [États-Unis] ; Kathryn H. Schmitz [États-Unis] ; Anna E. Prizment [États-Unis] ; Aaron R. Folsom [États-Unis]Source :
- Breast cancer research and treatment [ 0167-6806 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Composition corporelle, Facteurs de risque, Femelle, Humains, Iowa (épidémiologie), Lymphoedème (épidémiologie), Lymphoedème (étiologie), Noeuds lymphatiques (anatomopathologie), Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Survivants, Tumeurs du sein (), Tumeurs du sein (anatomopathologie).
- MESH :
- anatomopathologie : Noeuds lymphatiques, Tumeurs du sein.
- épidémiologie : Iowa, Lymphoedème.
- étiologie : Lymphoedème.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Body Composition, Breast Neoplasms (complications), Breast Neoplasms (pathology), Breast Neoplasms (therapy), Breast cancer, Epidemiology, Female, Health, Human, Humans, Iowa, Iowa (epidemiology), Lymph Nodes (pathology), Lymphedema, Lymphedema (epidemiology), Lymphedema (etiology), Middle Aged, Neoplasm Staging, Risk Factors, Risk factor, Survivor, Survivors, Woman.
- MESH :
- geographic , epidemiology : Iowa.
- complications : Breast Neoplasms.
- epidemiology : Lymphedema.
- etiology : Lymphedema.
- pathology : Breast Neoplasms, Lymph Nodes.
- therapy : Breast Neoplasms.
- Aged, Aged, 80 and over, Body Composition, Female, Humans, Middle Aged, Neoplasm Staging, Risk Factors, Survivors.
Abstract
Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], Ptrend = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], Ptrend = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors.
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Ahmed</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE</s1><s2>Minneapolis, MN 55455-0392</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, 921 Blockley Hall, 423 Guardian Drive</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Prizment, Anna E" sort="Prizment, Anna E" uniqKey="Prizment A" first="Anna E." last="Prizment">Anna E. 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Folsom</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300</s1><s2>Minneapolis, MN 55454</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Body Composition</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (therapy)</term><term>Breast cancer</term><term>Epidemiology</term><term>Female</term><term>Health</term><term>Human</term><term>Humans</term><term>Iowa</term><term>Iowa (epidemiology)</term><term>Lymph Nodes (pathology)</term><term>Lymphedema</term><term>Lymphedema (epidemiology)</term><term>Lymphedema (etiology)</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Risk Factors</term><term>Risk factor</term><term>Survivor</term><term>Survivors</term><term>Woman</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Composition corporelle</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Iowa (épidémiologie)</term><term>Lymphoedème (épidémiologie)</term><term>Lymphoedème (étiologie)</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survivants</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Iowa</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Noeuds lymphatiques</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Iowa</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Body Composition</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Risk Factors</term><term>Survivors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Composition corporelle</term><term>Facteur risque</term><term>Epidémiologie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lymphoedème</term><term>Cancer du sein</term><term>Homme</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survivant</term><term>Iowa</term><term>Femelle</term><term>Adulte</term><term>Femme</term><term>Santé</term><term>Survivants</term><term>Tumeurs du sein</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Adulte</term><term>Femme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], P<sub>trend</sub> = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], P<sub>trend</sub> = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Ahmed, Rehana L" sort="Ahmed, Rehana L" uniqKey="Ahmed R" first="Rehana L." last="Ahmed">Rehana L. Ahmed</name></region><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><name sortKey="Prizment, Anna E" sort="Prizment, Anna E" uniqKey="Prizment A" first="Anna E." last="Prizment">Anna E. Prizment</name><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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